Dr. Aparna Sen

M.Sc., Ph.D. (C.U)

Associate Professor & Head

Department of Microbiology

About me


Email ID                                                 : aparnasen_mac@yahoo.co.in

Academic Qualifications                       : M.Sc., Ph.D. in Biochemistry

Appointment                                         : West Bengal Education Service since 1992

Teaching                                                : UG (Chemistry Hons.) from  1992-2006 (14 years)
                                                                 UG (Microbiology Hons.) since 2002 (17 years)
                                                                PG (Microbiology) since 2005 (14 years)
                                                                PG Diploma Course since 2012 (6 years)

Subjects taught                                      : Chemistry of Biomolecules, Microbial Metabolism,
                                                                 Enzyme Kinetics, Medical Microbiology.
                                              
                                                                                                                        
Area of Research :

Reproductive and Developmental Biochemistry : Doctoral and Post-doctoral work
1. Biochemical & Biophysical studies on Human Placental Syncytiotrophoblast Basal Membranes.
2. Antioxidants and Lipid Peroxidation Studies in Human Fetoplacental System.
3. Protein Purification from Human Fetal Brain.

Current Research Activities:
Applied Microbiology :
Agricultural, Environmental and Industrial aspects of Microbiology:
1. Development of biofertilisers
2. Isolation and charaterisation of free living nitrogen fixing bacteria from soil.
3. Isolation and purification of industrially important enzymes eg. proteases, keratinases, amylases.
4. Bioremediation by polymer and plastic degrading and biosurfactant producing microbes.
5. Effects of Phytochemicals on Bacterial Biofilms.
6. Plant Growth Promotion and Microbes: Metagenomics.
Cancer Biology :
1.Effects of phytochemicals on cancer cell apoptosis, immunosuppression and systemic toxicity.
2. Synergistic applications of two or more  Natural Plant Products  or combinations of  Phytochemicals and Current Cancer Drugs in Cancer Therapeutics.
Research Projects handled:
⦁    “Isolation, Identification and Characterization of Free-living Nitrogen Fixing Bacteria with Salt Tolerant Properties from the Estuarine and Coastal Areas of West Bengal” UGC Minor Research Project undergone from 2007-2009.
⦁    “A mechanistic study on cancer cell apoptosis, amelioration of cancer-induced immunosuppression and systemic toxicity: Role of flavonoids”
CSIR Major Research Project for 3 years undergone from 2008-2011.
      3.   “Exploring the Impact of Triterpenoids on Integrity of Extracellular Matrix of Vibrio
             cholerae-Biofilms” UGC Minor Project  running from 2017 till date.

Research Scholars and Students guided:
1.  Summer Project Work Guide of Post Graduate student Sandhimita Mondal entitled “Isolation and Partial Characterisation of Free living Nitrogen fixing bacteria from saline soil around Matla River, Canning, South 24 Parganas” from June –August, 2007 in Bidhannagar College, Kolkata.
2. Final year Project Work Guide of Under Graduate student Kamal Mandal of Bengal Institute of Technology entitled “Capsaicin mediated treatment of cancer” from June-December, 2009 in Bidhannagar College and Bose Institute, Kolkata.
3.  Ph.D. Guide of Biswajit Saha registered in the Dept. of Biochemistry, Calcutta University.
Area of Research: Development of Biofertilisers.
6.  Ph.D. Guide of  Sudipta Paul Bhattacharya  registered in Dept. of  Biochemistry, Calcutta University. Area of Research: Effects of Triterpenoids on Bacterial Biofilms.

7. Ph.D. Guide of Soumi Biswas registered in the Dept. of Biochemistry, Calcutta University. Area of Research: Bioremediation Studies.
8.  Ph.D. Guide of Semanti Bhattacharya registered in the Dept. of Biochemistry, Calcutta University. Area of Research: Isolation, Purification and Characterisation of Antimicrobial Peptides.
9.  Ph.D. Guide of Aparna  Chakraborty to be registered. Area of Research: Isolation, Purification and Characterisation of  Important  Bioremedial Enzymes.
10. Ph.D. Guide of Sreetama Sengupta to be registered.  Area of Research:  Isolation, Purification  and Characterisation of Industrially important enzymes and their  Metagenomic Studies.

Publications


Important Publications:
  1. Aparna Sen and Manju Mukherjea : Modulation of bilayer fluidity by lipid peroxidation of human placental syncytiotrophoblast membranes during embryogenesis. Indian Journal of Biochemistry & Biophysics.,35,216-223, 1998.
2. Aparna Sen, Prabar K. Ghosh and Manju Mukherjea : Changes in lipid composition and fluidity of human placental basal membrane and modulation of bilayer protein functions with progress of gestation. Molecular and Cellular Biochemistry., 187, 183-190,1998.                  
3. Durba Mukhopadhyay, Prabar K. Ghosh, Aparna Sen and Manju Mukherjea : Fatty acid binding proteins from developing fetal brain;Characterisation and binding properties. Journal of Bioscience, 23, 605-612,1998.
4. Suparna Qanungo, Aparna Sen and Manju Mukherjea : Antioxidant status and lipid peroxidation in human fetoplacental unit. Clinica Chimica Acta., 285, 1-12, 1999.
5.Sandhimita Mondal, Abhijit Poddar, Sandip Bandopadhyay and Aparna Sen: Isolation and partial characterization of a free-living nitrogen fixing bacteria with phosphate solubilising and salt tolerant properties from soil collected from the coastal area of West Bengal. Indian Biologist, 40(2), 1-6, 2008.
 6. Samik Chakraborty, Minakshi Mazumdar, Shravanti Mukherjee, Pushpak Bhattacharjee, Arghya
          Adhikary, Argha Manna, Sreeparna Chakraborty, Poulami Khan, Aparna Sen and Tanya Das:
          Restoration of p53/miR-34a  regulatory axis decreases survival advantage and ensures Bax-
          dependent apoptosis of non- small cell lung carcinoma cells. FEBS Letters  588 (4) ,549-559,
          February 2014.

7. Samik Chakraborty, Arghya Adhikary, Minakshi Mazumdar, Shravanti Mukherjee, Pushpak Bhattacharjee, Deblina Guha, Tathagata Choudhuri, Samit Chattopadhyay, Gaurisankar Sa, Aparna Sen, Tanya Das: Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis.   PloS One, 2014; 9(6):e99743.
8. Biswajit Saha, Sangeeta Mishra, Sandhimita Mondal, Sandip Bandopadhyay
 and Aparna  Sen. Developing a good Biofertiliser : Isolation, Characterisation and Partial Identification of Growth Promoting Microorganisms with Potent  Nitrogen Fixing, Phosphate Solubilising and Salt Tolerant properties from  Soil around Coastal Area of West Bengal. Paper presented and abstracted in 101st Science Congress held at Jammu on 3-7 February, 2014, Abs E-9, p-83.
9. Lovely Rahaman, Sushanta Ghosh, Nandita Nath, Aparna Sen, Kiran Sharma and Bipin Kumar Sharma.; Extracts of Adhatoda vasica Nees. And vasicine  inhibits biofilm formation of Klebsiella pneumonia. IOSR Journal of Pharmacy and Biological Sciences e-ISSN: 2278-3008, p-ISSN:2319-7676. Volume 13, Issue 2 Ver. I (Mar. – Apr. 2018), PP 37-49 www.iosrjournals.org.
10.  Biswajit Saha  and Aparna Sen. Bioremediation of phosphate solubilising bacteria isolated from the nearby areas of Sundarban.  International Journal of Engineering, Science and Mathematics Vol. 7, Special Issue 4(3), April 2018, ISSN: 2320-0294.
11. Prasun Tribedi and Aparna Sen. Degradation of Low density poly ethylene (LDPE) by an isolated soil bacterium, Acinetobacter baumannii MPA1: a potential step towards sustainable environment remediation. Under review in Annals of Microbiology.

Others :
⦁    Member, Asiatic Society, Kolkata
⦁    Fellow of International Congress of Chemistry and Environment ( FICCE)
⦁    Fellow of Institute of Chemist (FIC)
Member of Indian Science Congress Association